Atezolizumab
CAS No. : 1380723-44-3
(Synonyms: MPDL3280A; RG-7446; RO-5541267)
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $670 | In-stock |
| 10mg | $1070 | In-stock |
| 25mg | $2050 | In-stock |
| 50mg | $3300 | In-stock |
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| Cat. No. : | HY-P9904 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.
In Vitro: Atezolizumab (0, 2.5, 5, 10, 20, and 40 μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway[1].
Atezolizumab (10 μg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].
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