ML198
CAS No. : 1380716-06-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $325 | In-stock |
| 50mg | $485 | In-stock |
| 100mg | $716 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117861 |
| M.Wt: | 290.32 |
| Formula: | C17H14N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C) |
ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC50 & Target: EC50: 0.4 μM (glucocerebrosidase)[1]
In Vitro: ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].
ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts[1].
ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].
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