Ceritinib dihydrochloride (Standard)
CAS No. : 1380575-43-8
(Synonyms: LDK378 (dihydrochloride) (Standard))
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| Cat. No. : | HY-15656AR |
| M.Wt: | 631.06 |
| Formula: | C28H38Cl3N5O3S |
| Purity: | >98 % |
| Solubility: |
Ceritinib (LDK378) dihydrochloride (Standard) is the analytical standard of Ceritinib dihydrochloride (HY-15656A). This product is intended for research and analytical applications. Ceritinib dihydrochloride is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency[1][2]. IC50 & Target:IC50: 0.2 nM (ALK), 8 nM (IGF-1R), 7 nM (InsR), 23 nM (STK22D)[1]
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