Lactisole (free acid)
CAS No. : 13794-15-5
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| Cat. No. : | HY-W030796 |
| M.Wt: | 196.20 |
| Formula: | C10H12O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets[1][2].
IC50 & Target:T1R3[1]
In Vitro:Lactisole free acid (3-10 mM; 48 h) does-dependently inhibits insulin secretion induced by Acesulfame-K, Sucralose (HY-N0614) and Glycyrrhizin (HY-N0184) in mouse pancreatic β-cells MIN6 (IC50~4 mM)[1].
Lactisole free acid (5 mM; 48 h) attenuates the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K without affecting the elevation of intracellular cAMP concentration ([cAMP]c)[1].
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