ML239


CAS No. : 1378872-36-6

1378872-36-6
Price and Availability of CAS No. : 1378872-36-6
Size Price Stock
5mg $55 In-stock
10mg $90 In-stock
25mg $200 In-stock
50mg $338 In-stock
100mg $585 In-stock
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Cat. No. : HY-19971
M.Wt: 346.60
Formula: C13H10Cl3N3O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1378872-36-6 :

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM. In Vitro: ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ∼24-fold selectivity against the control cell line[1]. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs)[2].

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