Zifaxaban
CAS No. : 1378266-98-8
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|---|---|---|
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| Cat. No. : | HY-122592 |
| M.Wt: | 429.88 |
| Formula: | C20H16ClN3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research[1].
IC50 & Target:IC50: 11.1 nM (human FXa)[1]
In Vivo:In venous thrombosis models in rats, Zifaxaban strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg, and its best efficacy time occurred at 2 h after administration[1].
In arteriovenous-shunt thrombosis and carotid thrombosis models in rats, Zifaxaban inhibits thrombus formation in a dose-dependent manner[1].
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