Cyclo(Arg-Gly-Asp-D-Phe-Val)
CAS No. : 137813-35-5
(Synonyms: Cyclo(RGDfV); C(RGDfV))
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| Cat. No. : | HY-P1613 |
| M.Wt: | 574.63 |
| Formula: | C26H38N8O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1]. IC50 & Target:αvβ3[1] In Vitro: Cyclo(Arg-Gly-Asp-d-Phe-Val) (Cyclo(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1].
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