MRS5698

MRS5698 is a selective G_i protein-coupled A₃ adenosine receptor (A₃AR) agonist, with K_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis^[1][2]. In Vitro: MRS5698 displays higher affinity and selectivity (>3000-fold) agonist A₃R vs. other adenosine receptor (ARs) in both human and mouse^[1].
MRS5698 (0.1-10 µM; 1 hours) induces a concentration-dependently robust A3R-mediated cAMP reduction in HEK-293T cells permanently expressing the A3R, regardless the illumination condition^[3]. In Vivo: MRS5698 (3 nmol/day; intrathecal injection for 25 days) prevents Oxaliplatin-induced mechano-allodynia and hyperalgesia, and attenuates Oxaliplatin-induced NLRP3/IL-1β neuroinflammation^[2].
MRS5698 (1 mg/kg; i.p. at days 2, 3 ) reduces the IL-23 induced (IL23 injected in day 0, 1, 3) ear thickness of C57BL/6N mouse during the third and fourth experimental days^[3].