Pembrolizumab
CAS No. : 1374853-91-4
(Synonyms: MK-3475; Lambrolizumab)
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $670 | In-stock |
| 10mg | $910 | In-stock |
| 25mg | $1600 | In-stock |
| 50mg | $2560 | In-stock |
| 100mg | $4000 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-P9902 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
IC50 & Target:PDCD1/PD-1/CD279
In Vitro:Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells[2].
Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells[2].
In Vivo:Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure[2].
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