BRD9539
CAS No. : 1374601-41-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $238 | In-stock |
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| Cat. No. : | HY-15647 |
| M.Wt: | 399.44 |
| Formula: | C24H21N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
BRD9539 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1[1].
In Vitro: BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells[1].
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays[1].
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