Dihydrexidine (hydrochloride)
CAS No. : 137417-08-4
(Synonyms: DAR-0100 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 1mg | $320 | In-stock |
| 5mg | $700 | In-stock |
| 10mg | $1100 | In-stock |
| 25mg | $2000 | In-stock |
| 50mg | $3300 | In-stock |
| 100mg | $4950 | In-stock |
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| Cat. No. : | HY-101299B |
| M.Wt: | 303.78 |
| Formula: | C17H18ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic);H2O : 10 mg/mL (ultrasonic) |
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5].
IC50 & Target:IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D2 dopamine receptor)[1]
In Vitro: Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells[5].
In Vivo: Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].
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