LAS-31180
CAS No. : 137338-43-3
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| Cat. No. : | HY-101811 |
| M.Wt: | 252.29 |
| Formula: | C11H12N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties. In Vitro: LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1]. In Vivo: In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].
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