Tilmicosin (phosphate)
CAS No. : 137330-13-3
(Synonyms: LY-177370 phosphate; EL-870 phosphate)
| Size | Price | Stock |
|---|---|---|
| 100mg | $30 | In-stock |
| 500mg | $60 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-B0905A |
| M.Wt: | 967.13 |
| Formula: | C46H83N2O17P |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : ≥ 100 mg/mL |
Tilmicosin (LY-177370) phosphate is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin phosphate mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin phosphate is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin phosphate has immunomodulatory and anti-inflammatory effects[1][2][3][4][5][6].
In Vitro:Non-salt dose:
Tilmicosin (0-7 μg/mL; 16-18 h) has the MIC for 90% of Staphylococcus aureus isolates from the bovine udder of 0.78 μg/mL[1].
Tilmicosin (0.5μg /mL; 2 h) induces apoptosis of bovine neutrophils[2].
Tilmicosin (5-20 μg/mL; 18 h) inhibits the expression of COX-2 and iNOS in LPS (HY-D1056) treated macrophages, and affects the secretion of cytokines[3].
In Vivo:Non-salt dose:
Tilmicosin (75 mg/kg; subcutaneous injection; single dose) induces cardiotoxicity in mice[4].
Pharmacokinetic Analysis in lung tissues of the M. gallisepticum infected chickens[5]
| Route | Dose (mg/kg) | t1/2kel (h) | Tmax (h) | Cmax (μg/g) | AUC (μg•h/g) | MRT (h) | CL/F (1/h/kg) |
| p.o. | 1 | 48.46 | 12.00 | 0.12 | 13.62 | 53.60 | 0.09 |
| p.o. | 30 | 50.60 | 12.00 | 6.19 | 464.23 | 50.88 | 0.06 |