Boc-Hyp-OH
CAS No. : 13726-69-7
| Size | Price | Stock |
|---|---|---|
| 10g | $8 | In-stock |
| 25g | $10 | In-stock |
| 100g | $27 | In-stock |
| 500g | $121 | In-stock |
| 1000g | $241 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-I0781 |
| M.Wt: | 231.25 |
| Formula: | C10H17NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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