Voriconazole (camphorsulfonate)
CAS No. : 137234-71-0
(Synonyms: UK-109496 (camphorsulfonate))
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| Cat. No. : | HY-76200B |
| M.Wt: | 581.61 |
| Formula: | C26H30F3N5O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
In Vitro: Voriconazole camphorsulfonate has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125–0.25 μg/mL, respectively[1].
Voriconazole camphorsulfonate inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth[2].
In Vivo: Voriconazole (5-20 mg/kg; p.o. for 21 days) camphorsulfonate prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) camphorsulfonate decreases the fungal burden in the lungs[3].
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