(4-Acetamidocyclohexyl) nitrate


CAS No. : 137213-91-3

(Synonyms: BM121307)

137213-91-3
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Cat. No. : HY-100295
M.Wt: 202.21
Formula: C8H14N2O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 137213-91-3 :

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator. In Vivo: The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].

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