Firuglipel
CAS No. : 1371591-51-3
(Synonyms: DS-8500a)
| Size | Price | Stock |
|---|---|---|
| 5mg | $680 | In-stock |
| 10mg | $1080 | In-stock |
| 25mg | $2150 | In-stock |
| 50mg | $3450 | In-stock |
| 100mg | $5500 | In-stock |
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| Cat. No. : | HY-109032 |
| M.Wt: | 467.49 |
| Formula: | C25H26FN3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist. IC50 & Target:GPR119[1] In Vitro: Firuglipel (DS-8500a) increases intracellular cAMP in a concentration-dependent manner in human, rat, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells, with EC50 values of 51.5, 98.4, and 108.1 nM, respectively. DS-8500a has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells[1]. In Vivo: Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats[1].
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