Elbasvir

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC₅₀s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively. IC50 & Target: EC50: 4 nM (HCV 1a), 3 nM (HCV 1b), 3 nM (HCV 2a)^[1] In Vitro: Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC₉₀ of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC₉₀ of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses^[1]. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC₅₀s in the low-picomolar range^[2].