(E)-FOBISIN101
CAS No. : 1370281-06-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $610 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $1960 | In-stock |
| 50mg | $3130 | In-stock |
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| Cat. No. : | HY-115501 |
| M.Wt: | 461.21 |
| Formula: | C15H11N3Na3O8P |
| Purity: | >98 % |
| Solubility: |
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research[1].
In Vitro:FOBISIN101 (5 mM; 3 days) forms a covalent adduct with Lys120 in purified 14-3-3ζ after X-ray radiation, occupying the peptide-binding groove and inactivating the protein[1].
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