SSE15206
CAS No. : 1370046-40-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $36 | In-stock |
| 25mg | $70 | In-stock |
| 50mg | $110 | In-stock |
| 100mg | $168 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111425 |
| M.Wt: | 371.45 |
| Formula: | C19H21N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells[1]. IC50 & Target: GI50: 197 nM (microtubule)[1]. In Vitro: SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines[1].
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