Lidocaine
CAS No. : 137-58-6
(Synonyms: Lignocaine)
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 5g | $66 | In-stock |
| 10g | $106 | In-stock |
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| Cat. No. : | HY-B0185 |
| M.Wt: | 234.34 |
| Formula: | C14H22N2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 5 mg/mL;DMSO : ≥ 100 mg/mL |
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
IC50 & Target: sodium channels[1], MEK/ERK, NF-κB[2]
In Vitro: Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].
In Vivo: Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].
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