D-Pantothenic acid (hemicalcium salt)

D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity^{[1][2][3][4][5][6][7][8]}。
In Vitro:D-Pantothenic acid (Vitamin B5, 1-2.5 mM) hemicalcium salt restrains Th17 cell differentiation through CoA in a PANK-dependent manner^[3].
D-Pantothenic acid (50-1000 µM, 3 days) hemicalcium salt inhibits RANKL induced osteoclastogenesis by scavenging ROS generation in BMMs cells^[5].
D-Pantothenic acid (2  mM, 4 days) hemicalcium salt rescues a membrane trafficking defect in human fibroblasts devoid of TANGO2^[8].
In Vivo:D-Pantothenic acid hemicalcium salt (10 mg/kg, oral gavage, daily) protects against obesity via brown adipose tissue activation in C57BL/6J mice^[4].
D-Pantothenic acid (Vitamin B5, 50mg/kg/day, drinking water, 2 weeks) hemicalcium salt alleviates experimental autoimmune encephalomyelitis in C57BL/6 mice^[3].
D-Pantothenic acid (pantothenic acid rich dietary, feed, four weeks) hemicalcium salt alleviates bone loss in an osteoporotic model of OVX mice^[5].
D-Pantothenic acid (0.1 mg/kg, p.o., starts from the day after infection and performs every day until the end of 4 weeks) hemicalcium salt reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with mycobacterium tuberculosis^[6].
D-Pantothenic acid (50  ppm, diet, 28 days) hemicalcium salt enhances intestinal development and alters microbes in weaned piglets, with enhancing the morphological structure, cell proliferation and differentiation of the ileum, cecum and colon^[7].