Lotilaner
CAS No. : 1369852-71-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $428 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $1120 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-116564 |
| M.Wt: | 596.76 |
| Formula: | C20H14Cl3F6N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1]. IC50 & Target:IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)[1] In Vitro:Lotilaner shows IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively[1].
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