SKA-111
CAS No. : 1369170-24-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $640 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-100418 |
| M.Wt: | 214.29 |
| Formula: | C12H10N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1].
In Vitro:SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
In Vivo:SKA-111 (1 μM for cardiac perfusion) improves Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart[1].
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