PD 123319 (ditrifluoroacetate)
CAS No. : 136676-91-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $127 | In-stock |
| 10mg | $158 | In-stock |
| 50mg | $528 | In-stock |
| 100mg | $760 | In-stock |
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| Cat. No. : | HY-10259A |
| M.Wt: | 736.66 |
| Formula: | C35H34F6N4O7 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 36 mg/mL |
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. IC50 & Target: IC50: 34 nM (AT2 Receptor)[1] In Vitro: PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2].
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