L 689037
CAS No. : 136668-50-3
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| Cat. No. : | HY-120580 |
| M.Wt: | 597.14 |
| Formula: | C36H37ClN2O4 |
| Purity: | >98 % |
| Solubility: |
L 689037 is a leukotriene biosynthesis (LT) inhibitor and a 5-lipoxygenase-activating protein (FLAP) binder. [125I]-L 691,831 serves as a standard probe to precisely locate the key structural domains that determine the binding of inhibitors to FLAP. L 689037 can be used in the research of asthma and inflammatory bowel disease[1]. In Vitro:L 689037 competes with [125I]-L-691,831 for binding to wild-type and select mutant human 5-lipoxygenase-activating protein expressed in COS-7 cell membranes with IC50 values ranging from 2 nM to 41 nM, while binding is undetectable for mutants with deletions in residues 48-61[1].
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