LTD4 antagonist 1
CAS No. : 136564-67-5
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| Cat. No. : | HY-U00359 |
| M.Wt: | 615.66 |
| Formula: | C31H32F3N3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM. IC50 & Target: Ki: 0.57 nM(LTD4)[1] In Vitro: LTD4 antagonist 1 (Compound 38b) exhibits a Ki of 0.57 nM for displacement of [3H]LTD4 on guinea pig lung membranes, a pKB of 9.93±0.14 versus LTE4 on guinea pig trachea[1]. In Vivo: LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].
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