Abacavir
CAS No. : 136470-78-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $114 | In-stock |
| 100mg | $144 | In-stock |
| 200mg | $180 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-17423 |
| M.Wt: | 286.34 |
| Formula: | C14H18N6O |
| Purity: | >98 % |
| Solubility: | H2O : 2 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
In Vitro:Abacavir (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion[1].
Abacavir induces fat apoptosis[4].
In Vivo:Abacavir (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].
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