Banoxantrone
CAS No. : 136470-65-0
(Synonyms: AQ4N)
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| Cat. No. : | HY-13562 |
| M.Wt: | 444.48 |
| Formula: | C22H28N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation[1][2]. In Vitro:Banoxantrone (20 μM; 90 min) selectively induces cells damage in hypoxia T50/80 tumour cells[1]. In Vivo:Banoxantrone (200 mg/kg; i.p.; single dose) significantly inhibits T50/80 tumours and induces cell damage in BDF mice[1].
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