YH239-EE
CAS No. : 1364488-67-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $78 | In-stock |
| 10mg | $122 | In-stock |
| 50mg | $487 | In-stock |
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| Cat. No. : | HY-12287 |
| M.Wt: | 504.41 |
| Formula: | C25H27Cl2N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 55 mg/mL |
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
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