CP-115953
CAS No. : 136440-70-5
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| Cat. No. : | HY-118569 |
| M.Wt: | 357.31 |
| Formula: | C19H13F2NO4 |
| Purity: | >98 % |
| Solubility: |
CP-115953 is an antitumor fluoroquinolone compound that targets eukaryotic topoisomerase II and Escherichia coli DNA gyrase. CP-115953 inhibits ATP hydrolysis and DNA relaxation by stimulating enzyme-mediated DNA cleavage, and enhances the expression of immune-related cytokines. CP-115953 is applicable for research on human cancers[1][2][3][4][5][6][7].
In Vitro:CP-115953 (0.78-100 μM; 96 h) inhibits the proliferation of PHA-stimulated human peripheral blood lymphocytes, with an EC50 of 3.1 μM after 96 h of incubation[6].
CP-115953 (0.78-100 μM; 96 h) inhibits DNA synthesis in human peripheral blood lymphocytes stimulated by Phytohemagglutinin (PHA) (HY-N7038) in a dose-dependent manner[6].
CP-115953 (0.78-100 μM; 48 h) stimulates IL-2 production in PHA-stimulated human peripheral blood lymphocytes in a dose-dependent manner[6].
CP-115953 (6.25-50 μM; 48 h) modulates IFN-γ production and cytokine mRNA expression in PHA-stimulated human peripheral blood lymphocytes[6].
CP-115953 (6 min) potently enhances Drosophila melanogaster topoisomerase II-mediated DNA cleavage, with an EC2 of 5 μM[3].
CP-115953 (up to 20 min) inhibits ATP hydrolysis catalyzed by Drosophila melanogaster topoisomerase II, with an IC50 value of 110 μM[3].
CP-115953 (50 μM; 6 min) exhibits DNA cleavage-enhancing activity against Drosophila melanogaster topoisomerase II[3].
CP-115953 potently enhances calf thymus topoisomerase II-mediated DNA cleavage, with an EC2 of 0.3 μM[4].
CP-115953 (15 min) inhibits calf thymus topoisomerase II-mediated DNA relaxation, with an IC50 of 3.2 μM[4].
CP-115953 (50 μM) does not significantly inhibit the strand-passing DNA ligation mediated by purified Drosophila melanogaster topoisomerase II[1].
CP-115953 (6 min) enhances the post-strand-passage double-stranded DNA cleavage mediated by purified Drosophila melanogaster topoisomerase II[1].
CP-115953 (15 min) inhibits DNA relaxation mediated by purified Drosophila melanogaster topoisomerase II, with an IC50 of approximately 50 μM[1].
CP-115953 (50 μM; 6 min) increases the level of Drosophila melanogaster topoisomerase II-DNA cleavage complexes without inhibiting enzyme-mediated DNA ligation[2].
CP-115953 (1 h) potently kills wild-type Chinese hamster ovary (CHO) cells, with an EC50 of approximately 9 μM[4].
CP-115953 (1 h) potently kills human A-431 squamous carcinoma cells, with an EC50 of approximately 14 μM[4].
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