Dinutuximab

Dinutuximab (APN-311) is a chimeric human-mouse anti-GD2 monoclonal antibody. Dinutuximab can bind to GD2 on the cell surface, triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and promoting tumor regression. Dinutuximab can inhibit the growth, invasion, and migration and induce apoptosis of tumor cells. Dinutuximab can be used in the research of tumors such as neuroblastoma and breast cancer^[1][2][3]. IC50 & Target:ganglioside GD2 In Vitro: Dinutuximab (0-5000 ng/mL; 0-12 days) can inhibit the adhesion, migration, and mammosphere formation, induce apoptosis of breast cancer cells MDA-MB-231, and inhibit the phosphorylation of mTOR, ERK, and 4E-BP1^[1].
Dinutuximab (100 ng/mL; 6-72 h), when used in combination with in vitro-activated natural killer cells (aNK) in human neuroblastoma cell lines SH-SY5Y-Fluc, CHLA-136-Fluc, and CHLA-255-Fluc, significantly reduces the viability and invasive ability of tumor cells^[2]. In Vivo: Dinutuximab (15 μg; tail vein injection; twice a week; 4 weeks) has anti-tumor activity in a mouse neuroblastoma model^[2].