MOMIPP
CAS No. : 1363421-46-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $142 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $800 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119624 |
| M.Wt: | 292.33 |
| Formula: | C18H16N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C) |
MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].
In Vitro: MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].
In Vivo: MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].
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