Absinthin
CAS No. : 1362-42-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $245 | In-stock |
| 5mg | $515 | In-stock |
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| Cat. No. : | HY-N0742 |
| M.Wt: | 496.64 |
| Formula: | C30H40O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46[1][2][3].
In Vitro: Absinthin (10 μM, 60 s) inhibits histamine-induced Ca2+ increases via hTAS2R46 in airway smooth muscle (ASM) cells[3].
Absinthin (1 and 10 μM, 1 h or 18 h) shows antioxidant activity, and inhibits PMA (HY-18739) induced superoxide anion production (1 h) and iNOS expression (18 h) in BEAS-2B cells[5].
In Vivo: Absinthin (20-80mg/kg, p.o.) relieves LPS-induced acute lung injury (reduces inflammatory cell infiltration and improves
lung architecture) in mice[4].
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