Rolofylline
CAS No. : 136199-02-5
(Synonyms: KW-3902)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $990 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10965 |
| M.Wt: | 356.46 |
| Formula: | C20H28N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450)[1]. Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases[2].
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