N-Palmitoyl dopamine
CAS No. : 136181-87-8
(Synonyms: PALDA)
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| Cat. No. : | HY-108455 |
| M.Wt: | 391.59 |
| Formula: | C24H41NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1]. In Vitro: PALDA (0.1-10 μM), the EC50 of N-arachidonoyl-dopamine (NADA) is lowered from approximately 90 to approximately 30 nM. The effect on intracellular Ca2+ by another endovanilloid, N-arachidonoyl-ethanolamine (anandamide, 50 nM), is also enhanced dose-dependently by PALDA. PALDA also acted in synergy with low pH (6.0-6.7) to enhance intracellular Ca2+ via TRPV1[1].
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