Lobetyol


CAS No. : 136171-87-4

136171-87-4
Price and Availability of CAS No. : 136171-87-4
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Cat. No. : HY-117652
M.Wt: 234.29
Formula: C14H18O3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 136171-87-4 :

Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro:Lobetyol (0-100 μg/mL, 0-48 h) leads to a dose-and time-dependent proliferation inhibition in MKN45 cells[1].
Lobetyol (0-100 μg/mL, 48 h) induces apoptosis and cell cycle arrest in a time- and dose-dependent manner in MKN45 cells[1].
Lobetyol (0-100 μg/mL, 48 h) increases the expression level of Bax, P53, and decreased the expression level of Bcl-2[1].
In Vivo:Lobetyol (0-10 mg/kg, Once per 3 days) suppresses tumor growth in MKN45 nude models[1].

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