(S)-(+)-Dimethindene (maleate)
CAS No. : 136152-65-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1400 | In-stock |
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| Cat. No. : | HY-107647 |
| M.Wt: | 408.49 |
| Formula: | C24H28N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48)[1]. IC50 & Target: pKi: 7.08 (M1), 7.78 (M2), 6.7(M3), 7(M4) In Vitro: (S)-(+)-Dimethindene maleate (2 μM; 1 h) significantly impaires the developmental potency of mouse extended pluripotent stem (mEPS) cells in chimeric blastocysts and leads to rapid differentiation of primed human pluripotent stem cell (hPSC)-converted hEPS cells[2].
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