SR9186
CAS No. : 1361414-26-7
(Synonyms: ML368)
| Size | Price | Stock |
|---|---|---|
| 1mg | $410 | In-stock |
| 5mg | $820 | In-stock |
| 10mg | $1230 | In-stock |
| 25mg | $2100 | In-stock |
| 50mg | $2950 | In-stock |
| 100mg | $4130 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120696 |
| M.Wt: | 430.46 |
| Formula: | C26H18N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C) |
SR9186 (ML368) is a selective CYP3A4 inhibitor with IC50 values of 9, 4, and 38 nM for Midazolam → 1'-hydroxymidazolam, Testosterone → 6β-hydroxytestosterone, and Vincristine → Vincristine M1, respectively. SR-9186 inhibits the development of hepatic-stage P. falciparum and blocks ivermectin metabolism. SR-9186 can be used in breast cancer research[1][2].
In Vitro:SR-9186 (4 nM-60 μM) selectively inhibits CYP3A4 with IC50 values of 9, 4, and 38 nM for Midazolam, Testosterone, and Vincristine (HY-N0488A) metabolism, respectively[1].
SR-9186 has a long half-life (106 min) in 1 mg/mL human liver microsomes, providing sustained CYP3A4 inhibition[1].
SR-9186 (2.5 μM; 20 min) reduces the formation of Lapatinib (HY-50898)-derived GSH adducts by 78% in pooled human liver microsomes[2].
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