RR-11a
CAS No. : 1361390-56-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $510 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1310 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112205 |
| M.Wt: | 560.51 |
| Formula: | C24H28N6O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI)[1][2][3].
IC50 & Target:Legumain[1]
In Vitro: Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].
In Vivo: Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
RR-11a (20 mg/kg; daily i.p. for 30 days) improves cardiac function, decreases cardiac rupture rate, and attenuates left chamber dilation and wall thinning post-AMI in mice[3].
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