AMG-1694
CAS No. : 1361217-07-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $450 | In-stock |
| 5mg | $1050 | In-stock |
| 10mg | $1465 | In-stock |
| 25mg | $2200 | In-stock |
| 50mg | $2720 | In-stock |
| 100mg | $3500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12614 |
| M.Wt: | 533.63 |
| Formula: | C23H30F3N3O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. IC50 & Target: IC50: 7 nM (GK-GKRP)[1] In Vitro: AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020?μM in the presence of GKRP[1].
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