Fidarestat
CAS No. : 136087-85-9
(Synonyms: SNK 860)
| Size | Price | Stock |
|---|---|---|
| 1mg | $63 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $256 | In-stock |
| 25mg | $560 | In-stock |
| 50mg | $925 | In-stock |
| 100mg | $1550 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-105185 |
| M.Wt: | 279.23 |
| Formula: | C12H10FN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. IC50 & Target: IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)[1] In Vitro: Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively[1]. In Vivo: Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats[2].
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