VHL Ligand 38


CAS No. : 1360616-29-0

1360616-29-0
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Cat. No. : HY-122570
M.Wt: 410.42
Formula: C21H22N4O5
Purity: >98 %
Solubility:
Introduction of 1360616-29-0 :

VHL Ligand 38 (Compound 1) is a competitive E3 ubiquitin-protein ligase VHL inhibitor with IC50s of 4.1 and 7.0 μM in 1% and 10% DMSO, respectively. VHL Ligand 38 contains a hydroxyproline residue and an isoxazolylacetamide fragment. VHL Ligand 38 significantly inhibits the binding of a fluorescent peptide derived from HIF1α (FAM-DEALA-Hyp-YIPD) (HY-P5908F) to VHL[1].

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