Angiotensin III, human, mouse
CAS No. : 13602-53-4
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| Cat. No. : | HY-P1540 |
| M.Wt: | 931.09 |
| Formula: | C46H66N12O9 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. IC50 & Target: IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)[1] In Vitro: Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1]. In Vivo: Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3].
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