Tetracaine (hydrochloride)


CAS No. : 136-47-0

(Synonyms: Amethocaine (hydrochloride))

136-47-0
Price and Availability of CAS No. : 136-47-0
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Cat. No. : HY-B0473
M.Wt: 300.82
Formula: C15H25ClN2O2
Purity: >98 %
Solubility: DMSO : ≥ 30 mg/mL;H2O : 50 mg/mL (ultrasonic)
Introduction of 136-47-0 :

Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic[1][2]. In Vitro: Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1][2].

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