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Oxythiamine


CAS No. : 136-16-3

(Synonyms: Hydroxythiamin)

136-16-3
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Cat. No. : HY-107430
M.Wt: 266.34
Formula: C12H16N3O2S
Purity: >98 %
Solubility: DMSO : 51.67 mg/mL (ultrasonic)
Introduction of 136-16-3 :

Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3]. IC50 & Target:Vitamin B1, Thiamine, Transketolase[1]. In Vitro: Oxythiamine (0-40 μM, 2 days) inhibits cell viability of MIA PaCa-2 cells (IC50: 14.95 μM)[1].
Oxythiamine chloride hydrochloride (0-500 μM, 48 h) suppresses expression of 14-3-3 protein beta/alpha in MIA PaCa-2 cells[1].
Oxythiamine (0.1-100 μM, 6-48 h) inhibits A549 cell proliferation[3].
Oxythiamine (0.1-100 μM, 24 h) induces A549 cell apoptosis[3].
Oxythiamine (0-20 μM) inhibits the invasion and migration (IC50: 8.75 μM) of Lewis lung carcinoma (LLC) cells[4].
In Vivo: Oxythiamine (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2].
Oxythiamine (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].

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