PAT-048
CAS No. : 1359983-15-5
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| Cat. No. : | HY-123522 |
| M.Wt: | 461.91 |
| Formula: | C22H18ClF2N3O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo[1][2].
IC50 & Target: IC50: 20 nM (Autotaxin, in mouse plasma)[1]
IC90: 200 nM (Autotaxin, in mouse plasma)[1]
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