Anagliptin (hydrochloride)
CAS No. : 1359670-56-6
(Synonyms: SK-0403 (hydrochloride))
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| Cat. No. : | HY-14877A |
| M.Wt: | 419.91 |
| Formula: | C19H26ClN7O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Anagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively[1].
IC50 & Target:IC50: 3.8 nM (DPP-4), 68 nM (DPP-8), 60 nM (DPP-9)[1]
In Vitro:Anagliptin (SK-0403) (0-100 μM; 24 h) attenuates s-DPP-4-induced smooth muscle cells proliferation[2].
Anagliptin (100 μM; 10 min) reduces TNF-α production in cultured monocytes[2].
Anagliptin (0.001-10 μM; 24 h) significantly suppresses sterol regulatory element‐binding protein activity in HepG2 cells (21% decrease)[3].
In Vivo:Anagliptin (SK-0403) (0.3%; in diet; 16 weeks) reduces atherosclerotic lesion and does not increase the number of circulating EPCs in apoliporotein E (apoE)-deficient mice[2].
Anagliptin (0.3%; in diet; 4 weeks) exhibits a lipid‐lowering effect in a hyperlipidemic mice model[3].
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