SR2211
CAS No. : 1359164-11-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $680 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16998 |
| M.Wt: | 527.48 |
| Formula: | C26H24F7N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. IC50 & Target: IC50: ~320 nM (RORγ), Ki: 105 nM (RORγ)[1][2]. In Vitro: The treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells[1].
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