SB-218078
CAS No. : 135897-06-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $138 | In-stock |
| 5mg | $345 | In-stock |
| 10mg | $570 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-107407 |
| M.Wt: | 393.39 |
| Formula: | C24H15N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest[1][2][3].
In Vitro: SB-218078 (2.5-5 μM; 18 hours; HeLa cells) treatment abrogates G2 cell cycle arrest caused by either γ-irradiation or a topoisomerase I Topotecan inhibition[1].
SB-218078 (500-625 μM; 96 hours; HeLa and HT-29 cells) treatment significantly increases the cytotoxicity of DNA damage [1].
In Vivo: SB-218078 (5 mg/kg; intraperitoneal injection; for 16 hours; C57/Bl6 mice) treatment could promote a strong increase of γ-H2AX and apoptosis throughout the lymphoma, while having no effect on a healthy spleen in Myc-induced lymphomas mouse model[2].
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